Based on the belief that physicians and other health professional can make a special contribution to the movement for nuclear disarmament and peace, and committed to promoting grassroots education, mobilization and activity to create a critical mass of citizens supporting these goals, PSR-Pittsburgh has established cooperative working relationships with a number of activist non-governmental organizations that play an important role in local civil society.

Most importantly, PSR-Pittsburgh is an active member of a coalition of more than 20 local groups devoted to nuclear disarmament, "ABOLITION 2000: The Western Pennsylvania Campaign to Abolish Nuclear Weapons". This coalition was named The Western Pennsylvania Campaign for a Comprehensive Test Ban, when founded in 1990, but changed to the present name , when its goal was achieved in 1996 by the adoption and signing of the Comprehensive Test Ban Treaty and the establishment of moratorium on nuclear tests by the declared nuclear nations.

Other partners of PSR-Pittsburgh (all members of the coalition) include Global Solutions (formerly World Federalist Association of Pittsburgh), Peace Links, and the Thomas Merton Center.